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CBD and Its Positive Effect on Anxiety, Depression and Other Stress-related Psychiatric Illness

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It has been known for some time that Cannabidiol (CBD) activates the Endocannabinoid System (ECS or eCB…with this blog, we’ll use the eCB nomenclature as that is the one used in the study we are referencing).  When the eCB is working well, our body can handle stress better. The problem, as we have alluded to in previous blogs, is that the eCB in most people does not function.  The nasty enzymes, FAAH and MAGL, eat away at our own endocannabinoids (Anandamide and 2-AG) and by doing so, they mostly render our eCB non-functional. Anandamide affects CB1 receptors whereas 2-AG has an affinity for both receptors.

Enter CBD and enter the realm of eCB activation and function.  Yes, CBD helps our endocannabinoid system to work better and by doing so, it restores homeostatic measures that help our body operate the way it was intended.  The effects are across the entire neurological system, although our blogs tend to usually only cover specific topics.

A great study in 2013, titled ‘Translational Evidence for The Involvement of the Endocannabinoid System in Stress-related Psychiatric Illnesses by Matthew Hill and Sabin Patel, published in Biology of Mood & Anxiety Disorders, discusses the value of the eCB and its effect on dampening the stress response and its help on balancing out mood.  Simply put, the eCB has a major hand in the proper functioning of our mood and attitude!

The authors reference both rodent and human studies.  Of greatest interest is the work in humans with post-traumatic stress disorder (PTSD), anxiety, and depression.  The authors discuss how activating CB1 receptors has been shown to have a ‘therapeutic benefit’ for anxiety and PTSD.  Apparently, it does so by dampening the activation of the amygdaloid in response to ‘threatening or adverse stimuli.’  This is a discussion worth having with your physician!

One of the major keys to reducing anxiety and other stress issues relies on your body’s ability to reduce the nasty enzymes FAAH and MAGL that we reference in almost all our blogs.  It’s quite convenient that CBD is the BEST known way to do so.  It’s not made from chemicals in a lab so it does not have the side effects that medications tend to have.  In fact, a lot of research is very specific about activating the endocannabinoid system to reduce depression. We know that inhibiting FAAH levels leads to an antidepressant effect.  Studies are now showing that in the case of several psychiatric conditions, there is a failure of endocannabinoid system signaling.  This means that the system is not working as it should.  This is not good as a properly functioning eCB is vital to our health.

More and more research is showing us the benefits of CBD for so many conditions.  If our eCB worked as it should, we wouldn’t need CBD. Sadly, too many of us do not have optimal health and our eCB is shut down. In this case, working to improve our health is vital and probably the best way to start this process is by using high quality, lab tested CBD.

Enjoy the NN lifestyle!

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4 Responses

  1. Bryan Johnson
    | Reply

    Hey Dr. Manison, is it safe to take ssri’s with cbd oil? I read that cbd can effect the way your liver processes medications leaving more in your system over time, which can potentially lead to overdose or other problems. I also read it can cause your blood pressure to drop. Any truth to this?

    • Dr. Allen Manison
      | Reply

      There is no drug interaction data in the research that I have seen save for the use of Warfarin, and this was a case study with a person with Marfan’s disease. The only interaction is that the CBD seemingly reduced the dose need of the Warfarin. Being CBD reduces systemic levels of FAAH and MAGL, the two enzymes that target your own endocannabinoids, your homeostatic abilities will be enhanced. This usually means that your body is going to work more efficiently. For those with high blood pressure, if systemic stress is reduced, then I suppose that the BP will be positively influenced. This would be important to monitor with someone who has those concerns. In regards to liver detoxification, we have to consider that with an upregulated system (better functioning) from the CBD that SSRIs and other psychotropic medications will need to be adjusted accordingly. This should be a good thing as less medications is generally desired, especially if CBD, which is very safe, can take its place. It is important to consult with your physician who has prescribed any medications to be sure he/she is in the loop in regards to what you are doing with CBD. I’d love to see PCPs and psychiatrists embrace CBD as a first line for many mental health issues vs. medications that have side effects. I believe that as the research continues to show benefits, more physicians will recommend CBD.

  2. Bella Dushner
    | Reply

    I was a call center agent for 2 years and a half. I worked in a graveyard shift so that’s why I am awake at night and sleep the whole day. And suddenly I quit my job because of my personal problem. And now I am having a hard time to sleep at night because I get used to being awake at night. Maybe one of the reason also is about my family problem. I really don’t know. So this is my problem now I want to sleep in a normal way but it didn’t happen, so I told my friend about this then he told me to try this CBD as a medicine I did not believe him at first coz i didn’t know anything about it. I don’t know if this will work or not. Can somebody help me with this? Or any suggestion. Thanks in advance.

    • Dr. Allen Manison
      | Reply


      It’s likely that your Endocannabinoid System is not working as it should. CBD can help restore its function. It might take a few weeks but you should see positive changes in perhaps many areas of health. One thing virtually all of the people using the Optimize 1050 tell us is that they are sleeping better…that seems to almost be an automatic. If you try it, please give us your feedback. We enjoy hearing how our products help people!

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