Help is here!
It has been known for some time that Cannabidiol (CBD) activates the Endocannabinoid System (ECS or eCB…with this blog, we’ll use the eCB nomenclature as that is the one used in the study we are referencing). When the eCB is working well, our body can handle stress better. The problem, as we have alluded to in previous blogs, is that the eCB in most people does not function. The nasty enzymes, FAAH and MAGL, eat away at our own endocannabinoids (Anandamide and 2-AG) and by doing so, they mostly render our eCB non-functional. Anandamide affects CB1 receptors whereas 2-AG has an affinity for both receptors.
Enter CBD and enter the realm of eCB activation and function. Yes, CBD helps our endocannabinoid system to work better and by doing so, it restores homeostatic measures that help our body operate the way it was intended. The effects are across the entire neurological system, although our blogs tend to usually only cover specific topics.
A great study in 2013, titled ‘Translational Evidence for The Involvement of the Endocannabinoid System in Stress-related Psychiatric Illnesses’ by Matthew Hill and Sabin Patel, published in Biology of Mood & Anxiety Disorders, discusses the value of the eCB and its effect on dampening the stress response and its help on balancing out mood. Simply put, the eCB has a major hand in the proper functioning of our mood and attitude!
The authors reference both rodent and human studies. Of greatest interest is the work in humans with post-traumatic stress disorder (PTSD), anxiety, and depression. The authors discuss how activating CB1 receptors has been shown to have a ‘therapeutic benefit’ for anxiety and PTSD. Apparently, it does so by dampening the activation of the amygdaloid in response to ‘threatening or adverse stimuli.’ This is a discussion worth having with your physician!
One of the major keys to reducing anxiety and other stress issues relies on your body’s ability to reduce the nasty enzymes FAAH and MAGL that we reference in almost all our blogs. It’s quite convenient that CBD is the BEST known way to do so. It’s not made from chemicals in a lab so it does not have the side effects that medications tend to have. In fact, a lot of research is very specific about activating the endocannabinoid system to reduce depression. We know that inhibiting FAAH levels leads to an antidepressant effect. Studies are now showing that in the case of several psychiatric conditions, there is a failure of endocannabinoid system signaling. This means that the system is not working as it should. This is not good as a properly functioning eCB is vital to our health.
More and more research is showing us the benefits of CBD for so many conditions. If our eCB worked as it should, we wouldn’t need CBD. Sadly, too many of us do not have optimal health and our eCB is shut down. In this case, working to improve our health is vital and probably the best way to start this process is by using high quality, lab tested CBD.
Enjoy the NN lifestyle!