1. CBD Health Benefits

 

Brain Benefits:

1.  Anxiety/Fear

Sachin Patel,Mathew N. Hill, Joseph F. Cheer, Carsten T. Wotjaki, Andrew Holmes, 2017. The endocannabinoid system as a target for novel anxiolytic drugs. Neuroscience and Biobehavioral Reviews, 76, 56-66

Fowler, Christopher, 2015. The potential of inhibitors of endocannabinoid metabolism as anxiolytic and antidepressive drugs—A practical view.  European Neuropsychopharmacology, 25, 749-762.

Christopher Norris, Michael Loureiro, Cecilia Kramar, Jordan Zunder, Justine Renard, Walter Rushlow, and Steven R Laviolette, 2016.  Cannabidiol Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System.  Neuropsychopharmacology, 41: 2839-2850.

2. PTSD

Bitencourt Rafael, Takahashi Reinaldo, 2018.  Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials. Frontiers in Neuroscience, 12, Article 502

3. Brain Injury

Molly Braun, Zenab T. Khan, Mohammad B. Khan, Manish Kumar, Ayobami Ward, Bhagelu R. Achyut, Ali S. Arbab, David C. Hess, Md. Nasrul Hoda, Babak Baban, Krishnan M. Dhandapani, Kumar Vaibhav, 2018.  Selective activation of cannabinoid receptor-2 reduces
neuroinflammation after traumatic brain injury via alternative
macrophage polarization. Brain, Behavior, and Immunity, 68: 224-237.

Schurman, Lesley, Lichtman Aron, 2017.  Endocannabinoids: A Promising Impact for Traumatic Brain Injury. Frontiers in Pharmacology, 8, Article 69

Ana Belen Lopez-Rodriguez, Virginia Mela, Estefania Acaz-Fonseca,Luis Miguel Garcia-Segura, Maria-Paz Viveros, 2016.  CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury.  Experimental Neurology, 279, 274-282.

4.  Anti-addiction Effect

Mélissa Prud’homme, Romulus Cata, and Didier Jutras-Aswad, 2015.  Cannabidiol as an Intervention for Addictive Behaviors- Libertas Academia, 9: 33–38.

Celia J.A. Morgan, Ravi K. Das, Alyssa Joye, H. Valerie Curran, Sunjeev K. Kamboj, 2013.  Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings.  Addictive Behaviors, 38: 2433-2436.

5.  Neurodegenerative Conditions

Tiziana Bisognoa, Sergio Oddic, Alessandra Piccoli, Domenico Faziob, Mauro Maccarrone, 2016.  Type-2 cannabinoid receptors in neurodegeneration. Pharmacological Research, 111, 721-730.

Vincenzo Micale, Vincenzo Di Marzo, Alexandra Sulcova, Carsten T. Wotjak, Filippo Drago, 2013.  Endocannabinoid system and mood disorders: Priming a target for new therapies. Pharmacology & Therapeutics, 138, 18-37

Alline C. Camposa, Manoela V. Fogac, Andreza B. Sonego,
Francisco S. Guimarãesa,, 2016.   Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacological Research, 112, 119-127.

6.  Autism Spectrum Disorder (ASD)

Erica Zamberletti , Marina Gabaglio and Daniela Parolaro, 2017.  The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models.  Intl J of Molecular Sciences, 18, 1-14.

7.  Epilepsy

Evan C. Rosenberg, Jay Louik, Erin Conway, Orrin Devinsky, and Daniel Friedman, 2017.  Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.  Epilepsia, 58(8), 96-100.

Archie A. Khan, Tawfeeq Shekh-Ahmad, Ayatakin Khalil, Matthew C. Walker and Afia B. Ali, 2018.  Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model. British Journal of Pharmacology, 175, 2097-2115.

William O. Pickrell,  Neil P. Robertson, 2017. Cannabidiol as a treatment for epilepsy. J Neurol 264, 2506-2508.

8.  Stroke Prevention

Scharf Eugene, 2017.  Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention. Cannabis and Cannabinoid Research, Vol. 2.1, 259-263.

9.  Migraine, Fibromyalgia, and Irritable Bowel Syndrome

Ethan B. Russo, 2004.  Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions?.  Neuroendocrinology Letters, Nos. 1/2, Vol, 25, 31-39.

10.  Mood Disorders

Vincenzo Micale, Vincenzo Di Marzo, Alexandra Sulcova, Carsten T. Wotjak, Filippo Drago, 2013.  Endocannabinoid system and mood disorders: Priming a target for new therapies.  138: 18-37.

Body Benefits:

11.  Reduces Pain/Anti-inflammatory

Alison Ribeiro, Viviane Ferraz-de-Paula, Milena L. Pinheiro, Luana B. Vitoretti, Domenica P. Mariano-Souza, Wanderley M. Quinteiro-Filho, Adriana T. Akamine, Vinícius I. Almeida, João Quevedo, Felipe Dal-Pizzol, Jaime E. Hallak, Antônio W. Zuardi, José A. Crippa, João Palermo-Neto, 2012.  Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptor. European Journal of Pharmacology, 678, 78-85.

Kevin P. Hill,  Matthew D. Palastro, Brian Johnson, and Joseph W. Ditre, 2017.  Cannabis and Pain: A Clinical Review.  Cannabis and Cannabinoid Research, Vol. 2.1, 96-104.

Natasha R. Ryz,  David J. Remillard, and Ethan B. Russo, 2017.  Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain.  Cannabis and Cannabinoid Research, Vol. 2.1, 210-216.

Antonio Calignano, Giovanna La Rana, Andrea Giuffrida, & Daniele Piomelli, 1998.  Control of pain initiation by endogenous cannabinoids.  Nature, Letters to the Editor. Vol. 394, 277-280.

J. Manzanares, M. D. Julian, and A. Carrascosa, 2006.  Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes.  Current Neuropharmacology, 4, 239-257.

12.  Blood Pressure and Heart Rate

Khalid A. Jadoon, Garry D. Tan, and Saoirse E. O’Sullivan, 2017.  A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight, 2 (11), 1-11

Sultan SR, Millar SA, England TJ, O’Sullivan SE., 2017.  A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol.  Front Pharmacology, 8:81, 1-13.

13.  Cardiac Protection

Asmaa I. Matouka, Ashraf Taye, Mohamed A. El-Moselhy, Gehan H. Heeba, Abdel A. Abdel-Rahmana, 2018.  Abnormal cannabidiol confers cardioprotection in diabetic rats independent of glycemic control.  European Journal of Pharmacology, 820, 256-264.

14.  Liver Protection

Yuping Wang, Partha Mukhopadhyay, Zongxian Cao, Hua Wang, Dechun Feng, György Haskó, Raphael Mechoulam, Bin Gao & Pal Pacher, 2017.  Cannabidiol attenuates alcohol induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. Scientific Reports, 7, 1-12

15.  Obesity

Dai Lu,  Rachel Dopart, Debra A. Kendall, 2016.  Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes.  Cell Stress and Chaperones, 21: 1-7.

E. Heyman, F.-X. Gamelin, J. Aucouturier and V. Di Marzo, 2012.  The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity.  Obesity Reviews, 13, 1110-1124.

16.  Bone

Lauren S. Whytea, Erik Rybergb, Natalie A. Simsc, Susan A. Ridgea, Ken Mackied, Peter J. Greasleyb, Ruth A. Rossa, and Michael J. Rogersa, 2009.  The putative cannabinoid receptor GPR55 affects
osteoclast function in vitro and bone mass in vivo. PNAS, Vol. 106, No. 38, 16511-16516.

Saif Deis, Raj Kamal Srivastava, Inigo Ruiz de Azua b, Laura Bindila, Saja Baraghithy, Beat Lutz, Itai Bab, Joseph Tamc, 2018.  Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor. Bone, 108, 34-42.

AymenI.Idris, StuartH.Ralston, 2012.  Role of cannabinoids in the regulation of bone remodeling.  Frontiers of Endocrinology, Vol. 3, Article 136, 1-8.

17.  Joint Health

Melissa O’Brien and Jason J McDougall, 2018.  Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids.  Current Opinion in Pharmacology, 40: 104-109.

18.  Arthritis

Holly T. Philpott, Melissa O’Brien, Jason J. McDougall, 2017.  Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.  Pain, Vol. 0, Number 0, 1-10.

19.  Skin

Gaewon Nam, Se Kyoo Jeong, Bu Man Park, Sin Hee Lee, Hyun Jong Kim, Seung-Phil Hong, Beomjoon Kim, Bong-Woo Kim, 2016.  Selective Cannabinoid Receptor-1 Agonists Regulate Mast Cell Activation in an Oxazolone-Induced Atopic Dermatitis Model.  Ann Dermatol, Vol. 28, No. 1, 22-29.

Jessica S. Mounessa, BS,  Julia A. Siegel, BA, Cory A. Dunnick, MD, and
Robert P. Dellavalle, MD, PhD, MSPH, 2017.  The role of cannabinoids in dermatology.  J Am Acad Dermatol, Vol. 77, No. 1, 188-190.

20.  Anti-tumor/anti-cancer

Paola Massi, Marta Solinas, Valentina Cinquina, & Daniela Parolaro, 2012.  Cannabidiol as potential anticancer drug.  BJCP, 75:2, 303-312.

Visnja Bogdanovic´, PhD, Jasminka Mrdjanovic´, PhD, and Ivana Borisev, PhD, 2017.  A Review of the Therapeutic Antitumor Potential of Cannabinoids.  The Journal of Alternative and Complementary Medicine, Vol. 00, No. 00, pp 1-6.