I have used the Noetic Nutraceuticals Optimize 2 ways and both have been very effective! The first use was to aid my recovery from a shoulder injury that, despite physical therapy, was not getting better. Using it consistently for a couple of weeks allowed me to heal and move away from pain. Currently I take .5 mL each morning and evening to support peri-menopause based sleep issues and moodiness. It is really helping!! I feel more “even” and less anxious. I plan to continue!