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The Lack of a Dose Response Curve with CBD and What It Means for You

By now, we all know the plethora of benefits from Cannabidiol (CBD).  If you have been reading our blogs, you know what we are talking about.

The amazing thing about all this great information with CBD is that there are no official or even unofficial dose response curves with CBD.  In regards to CBD, a dose response curve refers to the change in effect on a person (or other mammal) after it is exposed to a certain amount of CBD.  We could measure pain, inflammation, anxiety, depression, effects on different disease processes, etc…all based on a different doses of CBD.

Well, guess what?  There is nothing established for CBD.  Why is this?

At Noetic Nutraceuticals, we believe the answer is quite easy.  How does one easily quantify the damage to the neurological system?  This is no test that measures the activity of the Endocannabinoid System (eCB or ECS).  Being the eCB is essential for properly functioning homeostatic mechanisms in the body, it is truly a system that must be operating for us to function at an optimal level.

Each of us has different stressors and each stressor affects us in a unique fashion.  It is hard to quantify and qualify the effect of each irritant on our system.

We know that our bodies naturally produce the two antagonistic enzymes (FAAH and MAGL) that eat away at our endocannabinoids (Anandamide and 2-AG). With additional systemic stress, our bodies will produce more of these enzymes.  This further reduces the likelihood of our eCB working and this means we lose many of the necessary homeostatic mechanisms of our body.

One person with similar stressors might have bodily effects that are far different from another person with similar stressors.  This means that one person might need quite a different dose of CBD, and more importantly, might need whatever dose of CBD for a longer period of time to get the desired effects of activating the eCB.

To better illustrate my point, let’s say we have  two people who both weight 175 pounds.  One person has a family history of depression, has a stressful life, does not have a healthy dietary program, and does not exercise regularly. Let’s compare this lifestyle to one where the person has no family history of psychological issues, follows caloric restriction along with regular intermittent fasting with protein consumption based on lean body mass that has a high BV and a low acidic level, exercises regularly, has low stress levels, etc…  Now, do we only look at the weight and age of the person to consider a dose of CBD or do we factor in all the other considerations as well?  Certainly, it makes sense to evaluate the overall health of the person vs. just the age, weight, height, whatever else.  The proper functioning of our neurological system is dependent upon many factors and this should be the major consideration when we supplement with CBD.  I still believe too many people, and researchers alike, tend to oversimplify the power of the eCB and how it is unique with each individual.

This means we have to carefully consider how much CBD is really needed to trigger the eCB to function at a more optimal level.  Most of the studies tend to use high doses of CBD without comparing the results with lower levels of CBD.  This is understandable as many times people think that more is better for most everything.  However, as discussed above, what gets our eCB working optimally is different for each of us.  How much CBD does it ‘really’ take to activate it and keep it functioning well?  I believe that is the hard part to determine.  It’s easy for us to create products loaded with CBD and we could generate a lot of money doing so, but it’s simply not necessary.  Too many CBD companies are now producing super high doses of CBD and although we know CBD is healthy and has little to no side effects, it’s overkill.  The only side effects from CBD come into play with very high doses that we do not need and and we also have the ‘overflow’ effect, as we call it.

The ‘overflow effect’ refers to taking too much CBD and not needing it.  Let’s say a person would get desired effects with 25 mg/CBD per day but they are taking 100 mg/day.  The extra 75 mg does not serve a function and it tends to cost a lot of money.  We can likely assume that there are no side effects as CBD is safe, but overloading anything, if unnecessary, is a waste.

Barring an established dose response curve for CBD supplementation, we are going to continue to see ballooning dosing recommendations NOT based on any science.  We will also see unnecessarily high CBD level products selling for insane prices.  This problem will also lead to companies using synthetic cannabinoids, which we have learned in a previous blog can be deadly.  Who benefits from all of this if not the end-user?  Yeah…you got it right…the company selling it.

We appreciate you putting your trust in our products and we will always work hard to get you the best quality ingredients and innovative products on the market.  To read more about where NN stands on dosing with tinctures, please click here to read the page we have on our website dedicated to this topic.

Thank  you for living the NN lifestyle.

The statements in this blog have not been evaluated by the Food and Drug Administration. No statement in this blog or specific product discussed are intended to diagnose, treat, cure, or prevent any disease.  This blog is for informational purposes only.  We ask  you to discuss all matters of this blog with your doctor before beginning use of any products herein discussed.
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